Pub. Date : 2014
PMID : 25486480
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The oncogene EVI1 enhances transcriptional and biological responses of human myeloid cells to all-trans retinoic acid. | Tretinoin | MDS1 and EVI1 complex locus | Homo sapiens |
| 2 | Previous results from our laboratory have shown that EVI1 influenced transcription regulation in response to the myeloid differentiation inducing agent, all-trans retinoic acid (ATRA), in a dual manner: it enhanced ATRA induced transcription of the RARbeta gene, but repressed the ATRA induction of the EVI1 gene itself. | Tretinoin | MDS1 and EVI1 complex locus | Homo sapiens |
| 3 | Previous results from our laboratory have shown that EVI1 influenced transcription regulation in response to the myeloid differentiation inducing agent, all-trans retinoic acid (ATRA), in a dual manner: it enhanced ATRA induced transcription of the RARbeta gene, but repressed the ATRA induction of the EVI1 gene itself. | Tretinoin | MDS1 and EVI1 complex locus | Homo sapiens |
| 4 | Previous results from our laboratory have shown that EVI1 influenced transcription regulation in response to the myeloid differentiation inducing agent, all-trans retinoic acid (ATRA), in a dual manner: it enhanced ATRA induced transcription of the RARbeta gene, but repressed the ATRA induction of the EVI1 gene itself. | Tretinoin | MDS1 and EVI1 complex locus | Homo sapiens |
| 5 | Previous results from our laboratory have shown that EVI1 influenced transcription regulation in response to the myeloid differentiation inducing agent, all-trans retinoic acid (ATRA), in a dual manner: it enhanced ATRA induced transcription of the RARbeta gene, but repressed the ATRA induction of the EVI1 gene itself. | Tretinoin | MDS1 and EVI1 complex locus | Homo sapiens |
| 6 | In line with the gene expression results, EVI1 enhanced cell cycle arrest, differentiation, and apoptosis in response to ATRA, and knockdown of GDF15 counteracted some of these effects. | Tretinoin | MDS1 and EVI1 complex locus | Homo sapiens |