Pub. Date : 2014
PMID : 25486274
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Down-regulation of P2X7 by siRNA significantly attenuated ATP- or BzATP-driven migration and invasion of prostate cancer cells in vitro, and inhibited tumor invasiveness and metastases in nude mice. | 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |
| 2 | In addition, silencing of P2X7 remarkably attenuated ATP- or BzATP- driven expression changes of EMT/invasion-related genes Snail, E-cadherin, Claudin-1, IL-8 and MMP-3, and weakened the phosphorylation of PI3K/AKT and ERK1/2 in vitro. | 3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate | purinergic receptor P2X, ligand-gated ion channel, 7 | Mus musculus |