Pub. Date : 1989
PMID : 2548552
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We therefore investigated whether cilazapril, a structurally new and long-acting ACE inhibitor, interacts with angiotensin I-dependent changes in splanchnic haemodynamics in man, using an experimental model. | Cilazapril | angiotensinogen | Homo sapiens |
| 2 | The angiotensin I dependent increase in systemic and pulmonary resistance and pulmonary capillary wedge pressure was attenuated by cilazapril, as indicated by the shift of the dose-response curves to the right. | Cilazapril | angiotensinogen | Homo sapiens |
| 3 | These angiotensin I induced haemodynamic changes were clearly suppressed by cilazapril. | Cilazapril | angiotensinogen | Homo sapiens |
| 4 | We conclude that, in man, the influence of cilazapril on acute angiotensin I-mediated haemodynamic responses is present in the splanchnic vascular bed, and that the overall effects of cilazapril are consistent with both arterial and venous effects of the ACE inhibitor. | Cilazapril | angiotensinogen | Homo sapiens |
| 5 | Cilazapril effectively counteracts angiotensin I-induced splanchnic vasoconstriction. | Cilazapril | angiotensinogen | Homo sapiens |