Title : Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway.

Pub. Date : 2015

PMID : 25482933






1 Functional Relationships(s)
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1 In the present study, we determined the effect of dasatinib which was approved for imatinib resistant chronic myelogenous leukemia (CML) and (Ph(+)) acute lymphoblastic leukemia (ALL) treatment on P-gp-mediated MDR. Imatinib Mesylate ATP binding cassette subfamily B member 1 Homo sapiens