Title : Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway.

Pub. Date : 2015

PMID : 25482933






1 Functional Relationships(s)
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1 Our results showed that dasatinib significantly increased the sensitivity of P-gp-overexpressing MCF-7/Adr cells to doxorubicin in MTT assays; thus lead to an enhanced cytotoxicity of doxorubicin in MCF-7/Adr cells. monooxyethylene trimethylolpropane tristearate ATP binding cassette subfamily B member 1 Homo sapiens