Title : Renal human organic anion transporter 3 increases the susceptibility of lymphoma cells to bendamustine uptake.

Pub. Date : 2015 Feb 15

PMID : 25477469






4 Functional Relationships(s)
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1 We examined the effects of structural analogs of p-aminohippurate (PAH), melphalan, chlorambucil, and bendamustine, on OAT1-mediated [(3)H]PAH uptake and OAT3- and OAT4-mediated [(3)H]estrone sulfate (ES) uptake in stably transfected human embryonic kidney-293 cells. p-Aminohippuric Acid solute carrier family 22 member 6 Homo sapiens
2 We examined the effects of structural analogs of p-aminohippurate (PAH), melphalan, chlorambucil, and bendamustine, on OAT1-mediated [(3)H]PAH uptake and OAT3- and OAT4-mediated [(3)H]estrone sulfate (ES) uptake in stably transfected human embryonic kidney-293 cells. p-Aminohippuric Acid solute carrier family 22 member 6 Homo sapiens
3 We examined the effects of structural analogs of p-aminohippurate (PAH), melphalan, chlorambucil, and bendamustine, on OAT1-mediated [(3)H]PAH uptake and OAT3- and OAT4-mediated [(3)H]estrone sulfate (ES) uptake in stably transfected human embryonic kidney-293 cells. p-Aminohippuric Acid solute carrier family 22 member 6 Homo sapiens
4 Melphalan had no significant inhibitory effect on any OAT, whereas chlorambucil reduced OAT1-, OAT3-, and OAT4-mediated uptake of PAH or ES down to 14.6%, 16.3%, and 66.0% of control, respectively. p-Aminohippuric Acid solute carrier family 22 member 6 Homo sapiens