Title : Identification of coexistence of DNA methylation and H3K27me3 specifically in cancer cells as a promising target for epigenetic therapy.

Pub. Date : 2015 Feb

PMID : 25477340






2 Functional Relationships(s)
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1 Combined treatment with a DNA demethylating agent, 5-aza-2"-deoxycytidine (5-aza-dC) and an EZH2 inhibitor, GSK126, induced marked re-expression of genes with the dual modification, including known tumor-suppressor genes such as IGFBP7 and SFRP1, and showed an additive inhibitory effect on growth of cancer cells in vitro. Decitabine secreted frizzled related protein 1 Homo sapiens
2 Combined treatment with a DNA demethylating agent, 5-aza-2"-deoxycytidine (5-aza-dC) and an EZH2 inhibitor, GSK126, induced marked re-expression of genes with the dual modification, including known tumor-suppressor genes such as IGFBP7 and SFRP1, and showed an additive inhibitory effect on growth of cancer cells in vitro. Decitabine secreted frizzled related protein 1 Homo sapiens