Title : Prognostic value of microsatellite instability and p53 expression in metastatic colorectal cancer treated with oxaliplatin and fluoropyrimidine-based chemotherapy.

Pub. Date : 2014 Dec

PMID : 25474278






3 Functional Relationships(s)
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Protein Name
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1 The post-progression survival (PPS) of p53-positive patients undergoing 2nd and/or 3rd line chemotherapy with irinotecan and/or cetuximab was significantly longer compared to p53-negative patients. Irinotecan tumor protein p53 Homo sapiens
2 mCRC patients with p53 overexpression undergoing an irinotecan containing second- or third-line chemotherapy after oxaliplatin failure have a significantly longer post-progression survival compared to patients without p53 overexpression. Irinotecan tumor protein p53 Homo sapiens
3 To validate the clinical impact of p53 in patients with mCRC treated with irinotecan- and/or cetuximab further studies are needed. Irinotecan tumor protein p53 Homo sapiens