Title : Potentiation by adrenaline of thrombin-induced elevation of pHi is not essential for synergistic activation of human platelets.

Pub. Date : 1989 Jul 3

PMID : 2546796






4 Functional Relationships(s)
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1 Potentiation by adrenaline of thrombin-induced elevation of pHi is not essential for synergistic activation of human platelets. Epinephrine coagulation factor II, thrombin Homo sapiens
2 Adrenaline markedly enhanced the thrombin-induced increase in cytoplasmic pH (pHi) in BCECF-loaded platelets. Epinephrine coagulation factor II, thrombin Homo sapiens
3 The potentiation by adrenaline of thrombin-induced PLC activation measured as [32P]PA formation and final platelet responses was, however, not blocked by EIPA, even at low concentrations of thrombin. Epinephrine coagulation factor II, thrombin Homo sapiens
4 These results indicate that the enhancement by adrenaline of thrombin-induced cytoplasmic alkalinization may be a secondary effect which is not essential for the potentiation by adrenaline of platelet activation by thrombin. Epinephrine coagulation factor II, thrombin Homo sapiens