Title : Extracellular Na+ removal enhances granule secretion in platelets--evidence that Na+/H+ exchange is inhibitory to secretion induced by some agonists.

Pub. Date : 1989 Jul 3

PMID : 2546795






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Thus, (i) NH4Cl, which restored the increase in [pH]i in the absence of [Na+]e reduced the potentiated secretory response to thrombin, (ii) no increase in thrombin-induced secretion was observed when Na+ was replaced with Li+, which allowed a normal increase in [pH]i and (iii) ethyl isopropyl amiloride (EIPA) abolished the [pH]i rise and potentiated thrombin-induced secretion. Ammonium Chloride coagulation factor II, thrombin Homo sapiens