Title : Surface engineering of silica nanoparticles for oral insulin delivery: characterization and cell toxicity studies.

Pub. Date : 2014 Nov 1

PMID : 25466464






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1 The present work aimed at studying the interaction between insulin and SiNP surfaced with mucoadhesive polymers (chitosan, sodium alginate or polyethylene glycol) and the evaluation of their biocompatibility with HepG2 and Caco-2 cell lines, which mimic in vivo the target of insulin-loaded nanoparticles upon oral administration. Polyethylene Glycols insulin Homo sapiens