Pub. Date : 2015 Feb
PMID : 25464270
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CUL4B impedes stress-induced cellular senescence by dampening a p53-reactive oxygen species positive feedback loop. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 2 | Tumor suppressor p53 is known to regulate the level of intracellular reactive oxygen species (ROS). | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 3 | Tumor suppressor p53 is known to regulate the level of intracellular reactive oxygen species (ROS). | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 4 | We here report that a p53-ROS positive feedback loop drives a senescence program in normal human fibroblasts (NHFs) and this senescence-driving loop is negatively regulated by CUL4B. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 5 | We observed that p53-dependent ROS production was significantly augmented and stress-induced senescence was greatly enhanced when CUL4B was absent or depleted. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 6 | Together, our results established a critical role of CUL4B in negatively regulating the p53-ROS positive feedback loop that drives cellular senescence. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |