Title : Evaluation of the effect of apatinib (YN968D1) on cytochrome P450 enzymes with cocktail probe drugs in rats by UPLC-MS/MS.

Pub. Date : 2014 Dec 15

PMID : 25464097






1 Functional Relationships(s)
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1 Phenacetin, losartan, metoprolol and midazolam were used as the probe substrates for rat CYP1A2, CYP2C11, CYP2D4 and CYP3A1 enzymes, respectively. Phenacetin cytochrome P450, family 1, subfamily a, polypeptide 2 Rattus norvegicus