Title : New tetracyclic tacrine analogs containing pyrano[2,3-c]pyrazole: efficient synthesis, biological assessment and docking simulation study.

Pub. Date : 2015 Jan 7

PMID : 25462245






1 Functional Relationships(s)
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1 The docking study of compound 7h with AChE enzyme revealed that the (R)-enantiomer binds preferably to CAS while the (S)-enantiomer prone to be a PAS binder. Protactinium acetylcholinesterase (Cartwright blood group) Homo sapiens