Title : Discovery of new 7-substituted-4-imidazolylmethyl coumarins and 4'-substituted-2-imidazolyl acetophenones open analogues as potent and selective inhibitors of steroid-11β-hydroxylase.

Pub. Date : 2015 Jan 7

PMID : 25462231






1 Functional Relationships(s)
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1 Diseases triggered by an abnormally high level of cortisol (hypercortisolism), such as the Cushing"s and metabolic syndromes, could be successfully tackled by inhibitors of CYP11B1, a steroidal cytochrome P450 enzyme that catalyzes the last hydroxylation step of the cortisol biosynthesis. Hydrocortisone cytochrome P450 family 11 subfamily B member 1 Homo sapiens