Title : Rational design of novel CYP2A6 inhibitors.

Pub. Date : 2014 Dec 1

PMID : 25458499






1 Functional Relationships(s)
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1 The most potent CYP2A6 inhibitors were thienopyridine-2-carbaldehyde, benzothienophene-3-ylmethanamine, benzofuran-5-carbaldehyde and indole-5-carbaldehyde, with IC50 values below 0.5 muM for coumarin 7-hydroxylation. coumarin cytochrome P450 family 2 subfamily A member 6 Homo sapiens