Pub. Date : 2014 Dec 2
PMID : 25456436
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULT: BER significantly increased the metabolism of midazolam, phenacetin and tolbutamide by inducing the CYP1A2 and 3A4 enzyme in a dose-dependent manner, the mRNA and protein expression of CYP1A2 and 3A4 were increased by berberine at 1000ng mL(-1). | Phenacetin | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 2 | RESULT: BER significantly increased the metabolism of midazolam, phenacetin and tolbutamide by inducing the CYP1A2 and 3A4 enzyme in a dose-dependent manner, the mRNA and protein expression of CYP1A2 and 3A4 were increased by berberine at 1000ng mL(-1). | Phenacetin | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |
| 3 | CONCLUSION: BER increases the metabolism of cocktail drugs such as midazolam, phenacetin and tolbutamide by increasing the mRNA and protein expression of CYP1A2 and 3A4. | Phenacetin | cytochrome P450 family 1 subfamily A member 2 | Homo sapiens |