Title : 4-Functionalized 1,3-diarylpyrazoles bearing 6-aminosulfonylbenzothiazole moiety as potent inhibitors of carbonic anhydrase isoforms hCA I, II, IX and XII.

Pub. Date : 2014 Dec 15

PMID : 25456084






1 Functional Relationships(s)
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Protein Name
Organism
1 Against hCA II, all the compounds showed excellent to moderate inhibition with Ki values of compounds 5a, 5d, 5f, 6a-6f, 8d and 8f lower than 12nM (Ki of AZA). Acetazolamide carbonic anhydrase 2 Homo sapiens