Title : Temporary elimination of IL-10 enhanced the effectiveness of cyclophosphamide and BMDC-based therapy by decrease of the suppressor activity of MDSCs and activation of antitumour immune response.

Pub. Date : 2015 Mar

PMID : 25454807






4 Functional Relationships(s)
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1 Temporary elimination of IL-10 enhanced the effectiveness of cyclophosphamide and BMDC-based therapy by decrease of the suppressor activity of MDSCs and activation of antitumour immune response. Cyclophosphamide interleukin 10 Mus musculus
2 The high tumour growth inhibition was observed in mice treated with CY+anti-IL-10+BMDC/TAg as well as CY+-anti-IL-10+BMDC/TAg+BMDC/IL-12. Cyclophosphamide interleukin 10 Mus musculus
3 The high tumour growth inhibition was observed in mice treated with CY+anti-IL-10+BMDC/TAg as well as CY+-anti-IL-10+BMDC/TAg+BMDC/IL-12. Cyclophosphamide interleukin 10 Mus musculus
4 The high cytotoxic activity of spleen-derived NK cells and increased influx of these cells into tumours of mice treated with CY+anti-IL-10+BMDC/TAg indicate that mice from the group developed strong NK-dependent response. Cyclophosphamide interleukin 10 Mus musculus