Title : Activation of AKT/GSK3β pathway by TDZD-8 attenuates kainic acid induced neurodegeneration but not seizures in mice.

Pub. Date : 2015 Jan

PMID : 25453207






2 Functional Relationships(s)
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1 Although tonic-clonic seizure episodes evoked by KA were unaffected, TDZD-8 pretreatment decreased KA mediated elevation in caspase-3 cleavage as well as increased Bcl2 and phospho-GSK3beta (Ser9; pGSK3beta(Ser9)) expression. 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione caspase 3 Mus musculus
2 The findings suggest that activated GSK3beta orchestrated neurodegenerative alterations following KA treatment and its inhibition by TDZD-8 affords a distinct neuroprotective profile by activating Akt/GSK3beta pathway which might act upstream of Bax/Bcl2 and caspase-3 pathways. 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione caspase 3 Mus musculus