Title : Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis.

Pub. Date : 2015 Feb

PMID : 25452436






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 SUMMARY ANSWER: HMGB1 appears to be involved in regulating inflammatory reactions in testes, as HMGB1 is translocated from testicular cells during the course of EAO and blocking its action by ethyl pyruvate (EP) reduces disease progression and spermatogenic damage. ethyl pyruvate high mobility group box 1 Homo sapiens
2 SUMMARY ANSWER: HMGB1 appears to be involved in regulating inflammatory reactions in testes, as HMGB1 is translocated from testicular cells during the course of EAO and blocking its action by ethyl pyruvate (EP) reduces disease progression and spermatogenic damage. ethyl pyruvate high mobility group box 1 Homo sapiens