Title : Shikonin, a constituent of Lithospermum erythrorhizon exhibits anti-allergic effects by suppressing orphan nuclear receptor Nr4a family gene expression as a new prototype of calcineurin inhibitors in mast cells.

Pub. Date : 2014 Dec 5

PMID : 25451590






1 Functional Relationships(s)
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1 Indeed, shikonin inhibited the calcineurin activity to a similar extent as cyclosporin A that markedly suppressed the IgE/antigen-enhanced mRNA expression of TNF-alpha and the Nr4a family in mBMMCs. Cyclosporine tumor necrosis factor Homo sapiens