Title : Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis.

Pub. Date : 2015 Jan

PMID : 25451236






2 Functional Relationships(s)
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1 Upon bleomycin challenge, old mice experienced augmented PAI-1 induction and lung fibrosis as compared to young mice. Bleomycin serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus
2 Most interestingly, we show that fewer (myo)fibroblasts underwent apoptosis and more (myo)fibroblasts with increased level of PAI-1 accumulated in the lung of old than in young mice after bleomycin challenge. Bleomycin serine (or cysteine) peptidase inhibitor, clade E, member 1 Mus musculus