Title : Anabolic steroids activate calcineurin-NFAT signaling and thereby increase myotube size and reduce denervation atrophy.

Pub. Date : 2015 Jan 5

PMID : 25450864






3 Functional Relationships(s)
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1 We have recently demonstrated that nandrolone, a synthetic androgen, slows muscle atrophy after nerve transection associated with down-regulation of regulator of calcineurin 2 (RCAN2), a calcineurin inhibitor, suggesting a possible role of calcineurin-NFAT signaling. Nandrolone regulator of calcineurin 2 Rattus norvegicus
2 We have recently demonstrated that nandrolone, a synthetic androgen, slows muscle atrophy after nerve transection associated with down-regulation of regulator of calcineurin 2 (RCAN2), a calcineurin inhibitor, suggesting a possible role of calcineurin-NFAT signaling. Nandrolone regulator of calcineurin 2 Rattus norvegicus
3 Nandrolone also induced cell hypertrophy that was blocked by cyclosporin A or overexpression of RCAN2. Nandrolone regulator of calcineurin 2 Rattus norvegicus