Pub. Date : 2014 Dec 12
PMID : 25449280
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Further investigations showed that protection by SCF against H2O2 was mediated via activation of c-Kit-dependent Akt pathway. | Hydrogen Peroxide | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Inhibition of Akt activation, through pharmacological or genetic means, suppressed SCF-mediated anti-H2O2 activity in osteoblasts. | Hydrogen Peroxide | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | In summary, we have identified a new SCF-c-Kit-Akt physiologic pathway that protects osteoblasts from H2O2-induced damages, and might minimize the risk of osteonecrosis caused by oxidative stress. | Hydrogen Peroxide | thymoma viral proto-oncogene 1 | Mus musculus |