Title : Rosuvastatin attenuated the existing morphine tolerance in rats with L5 spinal nerve transection through inhibiting activation of astrocytes and phosphorylation of ERK42/44.

Pub. Date : 2015 Jan 1

PMID : 25445360






1 Functional Relationships(s)
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1 Additionally, the activation of astrocytes, the phosphorylation of extracellular signal-regulated kinase 42/44 (ERK(42/44)) and the expressions of TNFalpha and IL-1beta were inhibited significantly by rosuvastatin. Rosuvastatin Calcium tumor necrosis factor Rattus norvegicus