Title : Cytotoxic and multidrug resistance reversal activities of novel 1,4-dihydropyridines against human cancer cells.

Pub. Date : 2015 Jan 5

PMID : 25445037






1 Functional Relationships(s)
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1 Most DHPs, particularly compounds bearing 3-nitrophenyl (A2B2 and A3B2) and 4-nitrophenyl (A3B1 and A4B1) moieties at C4 significantly inhibited rhodamine 123 efflux at 5-25 microM, showing that the mechanism of MDR reversal by these agents is P-gp transporter modulation. Rhodamines ATP binding cassette subfamily B member 1 Homo sapiens