Pub. Date : 2015 Feb 1
PMID : 25444916
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin promotes apoptosis by activating the p53-miR-192-5p/215-XIAP pathway in non-small cell lung cancer. | Curcumin | tumor protein p53 | Homo sapiens |
| 2 | Curcumin also promoted miR-192-5p/215 expressions in A549 cells (p53 wild type) but not in H1299 cells (p53-null). | Curcumin | tumor protein p53 | Homo sapiens |
| 3 | Conditional knockdown of p53 by tetracycline inducible expression system significantly abrogated curcumin-induced miR-192-5p/215 upregulation in the p53 wild-type H460, A427 and A549 cells. | Curcumin | tumor protein p53 | Homo sapiens |
| 4 | Conditional knockdown of p53 by tetracycline inducible expression system significantly abrogated curcumin-induced miR-192-5p/215 upregulation in the p53 wild-type H460, A427 and A549 cells. | Curcumin | tumor protein p53 | Homo sapiens |
| 5 | Conversely, ectopic expression of exogenous wild-type but not R273H mutant p53 in the p53-null H1299 cells enabled miR-192-5p/215 response to curcumin treatment. | Curcumin | tumor protein p53 | Homo sapiens |
| 6 | Conversely, ectopic expression of exogenous wild-type but not R273H mutant p53 in the p53-null H1299 cells enabled miR-192-5p/215 response to curcumin treatment. | Curcumin | tumor protein p53 | Homo sapiens |
| 7 | Taken together, this study highlights that the proapoptotic effects of curcumin depend on miR-192-5p/215 induction and the p53-miR-192-5p/215-XIAP pathway is an important therapeutic target for non-small cell lung cancer. | Curcumin | tumor protein p53 | Homo sapiens |