Pub. Date : 1989 Jul
PMID : 2544398
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibitory effects of interleukin-1 on luteinizing hormone-stimulated adenosine 3",5"-monophosphate accumulation by cultured porcine granulosa cells. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |
| 2 | Pretreatment of the cells for 48 h with IL-1 reduced intra- and extracellular cAMP accumulation in response to LH by 73% and 83%, respectively. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |
| 3 | The lowest concentration of IL-1 used (0.5 pg/ml), in contrast, showed a tendency to stimulate LH-induced cAMP accumulation. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |
| 4 | IL-1 also significantly reduced intra- and extracellular cAMP accumulation by the cells in response to forskolin (50, 150 microM) by 28-46%, indicating that IL-1 can directly inhibit adenylate cyclase activity. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |
| 5 | IL-1 also significantly reduced intra- and extracellular cAMP accumulation by the cells in response to forskolin (50, 150 microM) by 28-46%, indicating that IL-1 can directly inhibit adenylate cyclase activity. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |
| 6 | These results indicate that the inhibitory effect of IL-1 on LH-stimulated progesterone secretion is due to its actions at at least two different sites along the LH-stimulated, cAMP-mediated, progesterone biosynthetic pathway, the LH receptor level and adenylate cyclase systems. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |