Title : Effects of anti-proliferative lichen metabolite, protolichesterinic acid on fatty acid synthase, cell signalling and drug response in breast cancer cells.

Pub. Date : 2014 Oct 15

PMID : 25442282






5 Functional Relationships(s)
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Protein Name
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1 AIMS: To test whether the anti-proliferative activity of (+)-PA is associated with effects on FASN and HER2 (human epidermal growth factor receptor 2) and major signalling pathways. Protactinium erb-b2 receptor tyrosine kinase 2 Homo sapiens
2 AIMS: To test whether the anti-proliferative activity of (+)-PA is associated with effects on FASN and HER2 (human epidermal growth factor receptor 2) and major signalling pathways. Protactinium erb-b2 receptor tyrosine kinase 2 Homo sapiens
3 RESULTS: Treatment with (+)-PA increased FASN expression in SK-BR-3 cells, which overexpress FASN and HER2, implying a compensatory response to inhibition of FASN activity. Protactinium erb-b2 receptor tyrosine kinase 2 Homo sapiens
4 Synergistic effects with lapatinib were seen only in SK-BR-3 cells, and not T-47D cells, further supporting the notion that (+)-PA acts by inhibiting FASN with secondary effects on HER2 expression and signalling. Protactinium erb-b2 receptor tyrosine kinase 2 Homo sapiens
5 (+)-PA could therefore be a suitable agent for further testing, alone or in combination treatment against HER2-overexpressing breast cancer. Protactinium erb-b2 receptor tyrosine kinase 2 Homo sapiens