Title : Inhibiting Lateral Habenula Improves L-DOPA-Induced Dyskinesia.

Pub. Date : 2016 Mar 1

PMID : 25442003






2 Functional Relationships(s)
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1 BACKGROUND: A systematic search of brain nuclei putatively involved in L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) in Parkinson"s disease shed light, notably, upon the lateral habenula (LHb), which displayed an overexpression of the FosB, ARC, and Zif268 immediate-early genes only in rats experiencing abnormal involuntary movements (AIMs). Levodopa FosB proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus
2 BACKGROUND: A systematic search of brain nuclei putatively involved in L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia (LID) in Parkinson"s disease shed light, notably, upon the lateral habenula (LHb), which displayed an overexpression of the FosB, ARC, and Zif268 immediate-early genes only in rats experiencing abnormal involuntary movements (AIMs). Levodopa FosB proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus