Title : Evaluation of the potential for pharmacokinetic drug-drug interaction between armodafinil and carbamazepine in healthy adults.

Pub. Date : 2015 Feb 1

PMID : 25438721






2 Functional Relationships(s)
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1 Armodafinil and the mood stabilizer carbamazepine are both inducers of and substrates for cytochrome P450 (CYP3A4). Modafinil cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 IMPLICATIONS: Systemic exposure to both carbamazepine and armodafinil was reduced after pretreatment with the other drug; systemic exposure to the metabolites of each drug, which are formed via CYP3A4, was increased. Modafinil cytochrome P450 family 3 subfamily A member 4 Homo sapiens