Title : Expression of P-gp in acute myeloid leukemia and the reversal function of As2O3 on drug resistance.

Pub. Date : 2015 Jan

PMID : 25435954






3 Functional Relationships(s)
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1 MDR1 expression was downregulated in certain patients following treatment with AS2O3. Arsenic Trioxide ATP binding cassette subfamily B member 1 Homo sapiens
2 In the present study, the overexpression of P-gp was the primary cause of drug resistance in the AML patients, and MDR1 expression was downregulated by As2O3 in primary leukemia and drug-resistant cells. Arsenic Trioxide ATP binding cassette subfamily B member 1 Homo sapiens
3 In the present study, the overexpression of P-gp was the primary cause of drug resistance in the AML patients, and MDR1 expression was downregulated by As2O3 in primary leukemia and drug-resistant cells. Arsenic Trioxide ATP binding cassette subfamily B member 1 Homo sapiens