Pub. Date : 2015 Feb
PMID : 25423498
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AIM: The aim of this paper was to compare the efficacy of in vitro calycosin and irbesartan for the treatment of angiotensin II (AngII)-induced renin angiotensin system (RAS) disorder in human umbilical vein endothelial cells (HUVECs). | 7,3'-dihydroxy-4'-methoxyisoflavone | angiotensinogen | Homo sapiens |
| 2 | AIM: The aim of this paper was to compare the efficacy of in vitro calycosin and irbesartan for the treatment of angiotensin II (AngII)-induced renin angiotensin system (RAS) disorder in human umbilical vein endothelial cells (HUVECs). | 7,3'-dihydroxy-4'-methoxyisoflavone | angiotensinogen | Homo sapiens |
| 3 | Interestingly, Calycosin was able to inhibit the effect of AngII in a concentration dependent manner, and its effect at concentration of 35 mumol was equal to that of positive control Irbesartan (10mumol). | 7,3'-dihydroxy-4'-methoxyisoflavone | angiotensinogen | Homo sapiens |
| 4 | CONCLUSION: Calycosin from Radix Astragali from Gansu province could protect HUVECs from AngII induced RAS disorder by downregulation of ACE expression and increased ACE2 expression, which is similar to irbesartan. | 7,3'-dihydroxy-4'-methoxyisoflavone | angiotensinogen | Homo sapiens |