Title : Hypochlorous acid generated by neutrophils inactivates ADAMTS13: an oxidative mechanism for regulating ADAMTS13 proteolytic activity during inflammation.

Pub. Date : 2015 Jan 16

PMID : 25422322






1 Functional Relationships(s)
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1 We exposed ADAMTS13 to hypochlorous acid (HOCl), produced by a myeloperoxidase-H2O2-Cl(-) system, and determined its residual proteolytic activity using both a VWF A2 peptide substrate and multimeric plasma VWF. Hypochlorous Acid myeloperoxidase Homo sapiens