Pub. Date : 2015 Feb
PMID : 25420507
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Voltage-gated K+ channel blocker quinidine inhibits proliferation and induces apoptosis by regulating expression of microRNAs in human glioma U87-MG cells. | Quinidine | potassium voltage-gated channel subfamily D member 3 | Homo sapiens |
| 2 | In the present study, we investigated the effect and mechanisms of quinidine, a commonly used voltage-gated K+ channel blocker, on cell proliferation and apoptosis of human glioma U87-MG cells. | Quinidine | potassium voltage-gated channel subfamily D member 3 | Homo sapiens |
| 3 | Furthermore, the concentration range of quinidine, which inhibited voltage-gated K+ channel currents in electrophysiological assay, was consistent with that of quinidine inhibiting cell proliferation and inducing cell apoptosis. | Quinidine | potassium voltage-gated channel subfamily D member 3 | Homo sapiens |
| 4 | Furthermore, the concentration range of quinidine, which inhibited voltage-gated K+ channel currents in electrophysiological assay, was consistent with that of quinidine inhibiting cell proliferation and inducing cell apoptosis. | Quinidine | potassium voltage-gated channel subfamily D member 3 | Homo sapiens |
| 5 | Taken together, these data suggested that the anti-proliferative and pro-apoptosis effect of voltage-gated K+ channel blocker quinidine in human glioma cells was mediated at least partly through regulating expression of miRNAs, and provided further support for the mechanisms of voltage-gated K+ channels in mediating cell proliferation and apoptosis. | Quinidine | potassium voltage-gated channel subfamily D member 3 | Homo sapiens |