Title : Second messenger signaling in the regulation of collagenase production by osteogenic sarcoma cells.

Pub. Date : 1989 Jun

PMID : 2542004






2 Functional Relationships(s)
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1 Incubation with the cAMP analog 8-bromo-cAMP (8BrcAMP) increased the number of collagenase-staining cells in a dose-dependent manner (ED0.5 = 2.5 x 10(-4) M), but to a lower level than PTH, with the maximal effect producing about 15% positive cells. 8-Bromo Cyclic Adenosine Monophosphate parathyroid hormone Rattus norvegicus
2 Incubation with the cAMP analog 8-bromo-cAMP (8BrcAMP) increased the number of collagenase-staining cells in a dose-dependent manner (ED0.5 = 2.5 x 10(-4) M), but to a lower level than PTH, with the maximal effect producing about 15% positive cells. 8-Bromo Cyclic Adenosine Monophosphate parathyroid hormone Rattus norvegicus