Pub. Date : 2014 Nov 4
PMID : 25418092
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cooperative binding of annexin A2 to cholesterol- and phosphatidylinositol-4,5-bisphosphate-containing bilayers. | Phosphatidylinositol 4,5-Diphosphate | annexin A2 | Homo sapiens |
| 2 | Here, we performed a quantitative analysis of the binding of AnxA2 to solid supported membranes containing the annexin binding lipids phosphatidylinositol-4,5-bisphosphate and phosphatidylserine in different compositions. | Phosphatidylinositol 4,5-Diphosphate | annexin A2 | Homo sapiens |
| 3 | Together our results reveal for the first time, to our knowledge, that AnxA2 and its derivatives bind cooperatively to membranes containing cholesterol, phosphatidylserine, and/or phosphatidylinositol-4,5-bisphosphate, thus providing a mechanistic model for the lipid clustering activity of AnxA2. | Phosphatidylinositol 4,5-Diphosphate | annexin A2 | Homo sapiens |