Title : Arsenic trioxide potentiates the anti-cancer activities of sorafenib against hepatocellular carcinoma by inhibiting Akt activation.

Pub. Date : 2015 Apr

PMID : 25416439






1 Functional Relationships(s)
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1 ATO downregulated the expression of Bcl-2 and Bcl-xL and upregulated the expression of Bax, indicating that ATO could induce the apoptosis of HCC cells through the intrinsic pathways; but sorafenib showed little effects on these proteins of Bcl-2 family. Arsenic Trioxide BCL2 like 1 Homo sapiens