Title : Simvastatin induces growth inhibition and apoptosis in HepG2 and Huh7 hepatocellular carcinoma cells via upregulation of Notch1 expression.

Pub. Date : 2015 Mar

PMID : 25412322






1 Functional Relationships(s)
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1 In addition, reverse transcription quantitative polymerase chain reaction and western blot analysis revealed that simvastatin-treated cells exhibited increased expression levles of Notch1, p53, and Bax, as well as decreased expression levels of B cell lymphoma 2; furthermore, Notch1 upregulation resulted in the inhibition of Akt phosphorylation. Simvastatin tumor protein p53 Homo sapiens