Title : Activation of volume-sensitive outwardly rectifying chloride channel by ROS contributes to ER stress and cardiac contractile dysfunction: involvement of CHOP through Wnt.

Pub. Date : 2014 Nov 20

PMID : 25412307






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Our study demonstrates a pivotal role of ROS/VSOR in mediating ER stress and functional impairment of cardiomyocytes via the CHOP-Wnt pathway, and suggests the therapeutic values of VSOR Cl(-) channel blockers against ER stress-associated cardiac anomalies. Reactive Oxygen Species DNA damage inducible transcript 3 Homo sapiens