Pub. Date : 2015 Feb
PMID : 25409894
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Characterization of CYP2B6 in a CYP2B6-humanized mouse model: inducibility in the liver by phenobarbital and dexamethasone and role in nicotine metabolism in vivo. | Phenobarbital | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | The inducibility of CYP2B6 by phenobarbital (PB) and dexamethasone (DEX), known inducers of CYP2B6 in human liver, was examined in the TG mice, as well as in TG/Cyp2abfgs-null (or "CYP2B6-humanized") mice. | Phenobarbital | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | The inducibility of CYP2B6 by phenobarbital (PB) and dexamethasone (DEX), known inducers of CYP2B6 in human liver, was examined in the TG mice, as well as in TG/Cyp2abfgs-null (or "CYP2B6-humanized") mice. | Phenobarbital | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | The inducibility of CYP2B6 by phenobarbital (PB) and dexamethasone (DEX), known inducers of CYP2B6 in human liver, was examined in the TG mice, as well as in TG/Cyp2abfgs-null (or "CYP2B6-humanized") mice. | Phenobarbital | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | The inducibility of CYP2B6 by phenobarbital (PB) and dexamethasone (DEX), known inducers of CYP2B6 in human liver, was examined in the TG mice, as well as in TG/Cyp2abfgs-null (or "CYP2B6-humanized") mice. | Phenobarbital | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 6 | Hepatic expression of CYP2B6 mRNA and protein was greatly induced by PB or DEX treatment in both TG and TG/Cyp2abfgs-null mice. | Phenobarbital | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 7 | In PB-treated mice, the rates of hepatic microsomal hydroxybupropion formation (at 50 muM bupropion) were >4-fold higher in TG/Cyp2abfgs-null than in Cyp2abfgs-null mice (for both male and female mice); the rate difference was accompanied by a 5-fold higher catalytic efficiency in the TG/Cyp2abfgs-null mice and was abolished by an antibody to CYP2B6. | Phenobarbital | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |