Pub. Date : 2015 Feb
PMID : 25409894
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Characterization of CYP2B6 in a CYP2B6-humanized mouse model: inducibility in the liver by phenobarbital and dexamethasone and role in nicotine metabolism in vivo. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | The ability of CYP2B6 to metabolize nicotine was then examined, both in vitro and in vivo. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | Thus, the transgenic CYP2B6 was inducible and functional, and, in the absence of mouse CYP2A and CYP2B enzymes, it contributed to nicotine metabolism in vivo. | Nicotine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |