Title : Selective inhibition of RET mediated cell proliferation in vitro by the kinase inhibitor SPP86.

Pub. Date : 2014 Nov 20

PMID : 25409876






1 Functional Relationships(s)
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1 In MCF7 cells, SPP86 inhibited RET- induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling and estrogen receptoralpha (ERalpha) phosphorylation, and inhibited proliferation to a similar degree as tamoxifen. Tamoxifen ret proto-oncogene Homo sapiens