Title : Pharmacological profile of opicapone, a third-generation nitrocatechol catechol-O-methyl transferase inhibitor, in the rat.

Pub. Date : 2015 Apr

PMID : 25409768






1 Functional Relationships(s)
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1 CONCLUSIONS AND IMPLICATIONS: Opicapone has a prolonged inhibitory effect on peripheral COMT, which extends the bioavailability of levodopa, without inducing toxicity. Levodopa catechol-O-methyltransferase Rattus norvegicus