Pub. Date : 2015 Jan 15
PMID : 25406263
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Somatostatin and insulin mediate glucose-inhibited glucagon secretion in the pancreatic alpha-cell by lowering cAMP. | Cyclic AMP | insulin | Homo sapiens |
| 2 | This decrease is driven by the combination of somatostatin, which inhibits adenylyl cyclase production of cAMP via the Galphai subunit of the SSTR2, and insulin, which acts via its receptor to activate phosphodiesterase 3B and degrade cytosolic cAMP. | Cyclic AMP | insulin | Homo sapiens |
| 3 | Our data indicate that both somatostatin and insulin signaling are required to suppress cAMP/PKA and glucagon secretion from both human and murine alpha-cells, and the combination of these two signaling mechanisms is sufficient to reduce glucagon secretion from isolated alpha-cells as well as islets. | Cyclic AMP | insulin | Homo sapiens |
| 4 | Thus, we conclude that somatostatin and insulin together are critical paracrine mediators of glucose-inhibited glucagon secretion and function by lowering cAMP/PKA signaling with increasing glucose. | Cyclic AMP | insulin | Homo sapiens |