Pub. Date : 2015 Jan 15
PMID : 25406263
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Our data indicate that both somatostatin and insulin signaling are required to suppress cAMP/PKA and glucagon secretion from both human and murine alpha-cells, and the combination of these two signaling mechanisms is sufficient to reduce glucagon secretion from isolated alpha-cells as well as islets. | Glucagon | insulin | Homo sapiens |
| 2 | Our data indicate that both somatostatin and insulin signaling are required to suppress cAMP/PKA and glucagon secretion from both human and murine alpha-cells, and the combination of these two signaling mechanisms is sufficient to reduce glucagon secretion from isolated alpha-cells as well as islets. | Glucagon | insulin | Homo sapiens |
| 3 | Thus, we conclude that somatostatin and insulin together are critical paracrine mediators of glucose-inhibited glucagon secretion and function by lowering cAMP/PKA signaling with increasing glucose. | Glucagon | insulin | Homo sapiens |