Pub. Date : 1989 Apr
PMID : 2540210
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interleukin 1 stimulates prostaglandin synthesis and cyclic AMP accumulation in Swiss 3T3 fibroblasts: interactions between two second messenger systems. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |
| 2 | IL-1 also stimulated cAMP accumulation. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |
| 3 | Indomethacin blocked cAMP accumulation in response to IL-1, suggesting that PGE2 was responsible for the increase. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |
| 4 | PGE2 augmented thymidine incorporation by increasing cAMP accumulation because in the presence of indomethacin addition of exogenous cAMP enhanced thymidine incorporation in response to low concentrations of IL-1. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |
| 5 | PGE2, in turn, stimulates cAMP accumulation which potentiates IL-1-stimulated PGE2 synthesis and thymidine incorporation. | Cyclic AMP | interleukin 1 alpha | Homo sapiens |