Pub. Date : 2014
PMID : 25400942
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Leucine Modulates Mitochondrial Biogenesis and SIRT1-AMPK Signaling in C2C12 Myotubes. | Leucine | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 2 | Moreover, beta-hydroxy-beta-methyl butyrate (HMB), a metabolite of leucine, has been reported to activate AMPK synergistically with resveratrol in C2C12 myotubes. | Leucine | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 3 | Therefore, we hypothesize that leucine-induced activation of SIRT1 and AMPK is the central event that links the upregulated mitochondrial biogenesis and fatty acid oxidation in skeletal muscle. | Leucine | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 4 | Furthermore, leucine treatment for 24 hours resulted in time-dependent increases in cellular NAD(+), SIRT1 activity, and p-AMPK level, with SIRT1 activation preceding that of AMPK, indicating that leucine activation of SIRT1, rather than AMPK, is the primary event. | Leucine | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 5 | Furthermore, leucine treatment for 24 hours resulted in time-dependent increases in cellular NAD(+), SIRT1 activity, and p-AMPK level, with SIRT1 activation preceding that of AMPK, indicating that leucine activation of SIRT1, rather than AMPK, is the primary event. | Leucine | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 6 | Furthermore, leucine treatment for 24 hours resulted in time-dependent increases in cellular NAD(+), SIRT1 activity, and p-AMPK level, with SIRT1 activation preceding that of AMPK, indicating that leucine activation of SIRT1, rather than AMPK, is the primary event. | Leucine | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 7 | Furthermore, leucine treatment for 24 hours resulted in time-dependent increases in cellular NAD(+), SIRT1 activity, and p-AMPK level, with SIRT1 activation preceding that of AMPK, indicating that leucine activation of SIRT1, rather than AMPK, is the primary event. | Leucine | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 8 | Furthermore, leucine treatment for 24 hours resulted in time-dependent increases in cellular NAD(+), SIRT1 activity, and p-AMPK level, with SIRT1 activation preceding that of AMPK, indicating that leucine activation of SIRT1, rather than AMPK, is the primary event. | Leucine | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |
| 9 | Furthermore, leucine treatment for 24 hours resulted in time-dependent increases in cellular NAD(+), SIRT1 activity, and p-AMPK level, with SIRT1 activation preceding that of AMPK, indicating that leucine activation of SIRT1, rather than AMPK, is the primary event. | Leucine | protein kinase AMP-activated non-catalytic subunit beta 1 | Homo sapiens |