Pub. Date : 2015 Jun 15
PMID : 25400033
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | To investigate the predictive and prognostic value of O(6) -methylguanine DNA methyltransferase (MGMT) inactivation by analyses of promoter methylation in pretreatment tumor biopsies from patients with cutaneous melanoma treated with dacarbazine (DTIC) or temozolomide (TMZ) were performed. | Dacarbazine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 2 | To investigate the predictive and prognostic value of O(6) -methylguanine DNA methyltransferase (MGMT) inactivation by analyses of promoter methylation in pretreatment tumor biopsies from patients with cutaneous melanoma treated with dacarbazine (DTIC) or temozolomide (TMZ) were performed. | Dacarbazine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 3 | To investigate the predictive and prognostic value of O(6) -methylguanine DNA methyltransferase (MGMT) inactivation by analyses of promoter methylation in pretreatment tumor biopsies from patients with cutaneous melanoma treated with dacarbazine (DTIC) or temozolomide (TMZ) were performed. | Dacarbazine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 4 | To investigate the predictive and prognostic value of O(6) -methylguanine DNA methyltransferase (MGMT) inactivation by analyses of promoter methylation in pretreatment tumor biopsies from patients with cutaneous melanoma treated with dacarbazine (DTIC) or temozolomide (TMZ) were performed. | Dacarbazine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 5 | DTIC/TMZ therapy response rate was found to be significantly associated with MGMT promoter methylation in cohort S (p = 0.0005), but did not reach significance in cohort C (p = 0.16). | Dacarbazine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |
| 6 | Together, this implies that MGMT promoter methylation is associated with response to single-agent DTIC/TMZ and longer PFS in disseminated cutaneous melanoma. | Dacarbazine | O-6-methylguanine-DNA methyltransferase | Homo sapiens |